COMMONALITIES AND CONTRASTS: AN INVESTIGATION OF ERP USABILITY IN A COMPARATIVE USER STUDY

In recent years, several user studies have examined specific usability problems in the field of Enterprise Resource Planning (ERP). These studies focused on different branches, various usability aspects, and several user groups. In spite of this diversification, some common and essential usability problems have become apparent, which are related to system complexity and difficulties in finding required information. However, these findings are based on the situation in a specific country, a singular ERP system and few data samples. Therefore, this paper aims at complementing the related work by results from a comparative user survey from two different European countries: Germany and Latvia. The survey is based on 184 ERP users from Germany and 24 ERP users from Latvia. The results indicated that both countries have several contrasts, but also diverse commonalities in industry, ERP market and culture. However, users in both countries are very homogenous with regard to the assessment of usability problems in their ERP interfaces. This paper investigates elementary usability problems derived from the related work and examines to which extent they are valid in both countries today. The main hypothesis claims that diverse national characteristics do not necessarily lead to a different assessment of usability problems in ERP systems

Defizite und Potentiale im Bereich der Usability betriebswirtschaftlicher Anwendungen in Kleinst-, Klein- und mittelständischen Unternehmen am Beispiel des Freistaats Sachsen

Die Mehrheit betriebswirtschaftlicher Anwendungen nutzt zur Darstellung formularbasierte Dialoge, Menüs und tabellarische Auflistungen. Das damit verbundene Defizit äußert sich in der vollumfänglichen Präsentation des Informationsraums (z.B. in Form einer Tabelle mit mehreren tausend Datensätzen). Die Möglichkeiten, den Detailgrad sowie die Darstellungs-form der Informationen zu bestimmen, sind nur sehr eingeschränkt vorhanden. Zudem muss der Anwender über Kenntnisse der Dialogstruktur verfügen, um mit den Daten sowie den Operationen auf ihnen umgehen zu können. Die vorliegende Studie soll die Potentiale und Defizite am Beispiel des Freistaats Sachsen genauer untersuchen. Sie soll zudem Aufschluss darüber geben, welche Bedürfnisse bezüglich der Benutzeroberfläche vorhanden sind und welchen Schwerpunkten sich anschließende Forschungsfragen widmen sollten

In-Memory basierte Real-Time Supply Chain Planung

Veränderte produktionslogistische Rahmenbedingungen und neue Ziele im Supply Chain Management (SCM) erfordern ein Redesign aktueller Supply Chain Planning (SCP)-Systeme. In-Memory-basierte betriebliche Informationssysteme bieten viele Vorteile und können bei der Definition neuer SCM-Systeme zugrunde gelegt werden. Allerdings sind noch Defizite in der Datenorganisation und den User Interfaces zu überwinden sowie Geschäftsprozesse anzupassen. Basierend auf den Erfahrungen aus mehreren Forschungsprojekten und den dort praktisch realisierten Demonstratoren werden die Eigenschaften von Real-Time-SCP-Lösungen definiert und anhand des Sales and Operations Planning (SOP)-Prozesses Perspektiven zur Überwindung bestehender Defizite aufgezeigt

Constraining mid to late Holocene relative sea level change in the southern equatorial Pacific Ocean relative to the Society Islands, French Polynesia

Precisely quantifying the current climate-related sea level change requires accurate knowledge of long-term geological processes known as Glacial Isostatic Adjustments (GIA). Although the major postglacial melting phase is likely to have ended ∼6–4 ka BP (before present), GIA is still significantly affecting the present-day vertical position of the mean sea surface and the sea bottom. Here we present empirical rsl (relative sea level) data based on U/Th dated fossil corals from reef platforms of the Society Islands, French Polynesia, together with the corresponding GIA-modeling. Fossil coral data constrain the timing and amplitude of rsl variations after the Holocene sea level maximum (HSLM). Upon correction for isostatic island subsidence, we find that local rsl was at least ∼1.5 ± 0.4 m higher than present at ∼5.4 ka. Later, minor amplitude variations occurred until ∼2 ka, when the rsl started dropping to its present position with a rate of ∼0.4 mm/yr. The data match with predicted rsl curves based on global ice-sheet chronologies confirming the role of GIA-induced ocean siphoning effect throughout the mid to late Holocene. A long lasting Late Holocene highstand superimposed with second-order amplitudinal fluctuations as seen from our data suggest that the theoretical predicted timing of rsl change can still be refined pending future calibration

Subducting slabs: jellyfishes in the Earth mantle

International audienceThe constantly improving resolution of geophysical data, seismic tomography and seismicity in particular, shows that the lithosphere does not subduct as a slab of uniform thickness but is rather thinned in the upper mantle and thickened around the transition zone between the upper and lower mantle. This observation has traditionally been interpreted as evidence for the buckling and piling of slabs at the boundary between the upper and lower mantle, where a strong contrast in viscosity may exist and cause resistance to the penetration of slabs into the lower mantle. The distribution and character of seismicity reveal, however, that slabs undergo vertical extension in the upper mantle and compression near the transition zone. In this paper, we demonstrate that during the subduction process, the shape of low viscosity slabs (1 to 100 times more viscous than the surrounding mantle) evolves toward an inverted plume shape that we coin jellyfish. Results of a 3D numerical model show that the leading tip of slabs deform toward a rounded head skirted by lateral tentacles that emerge from the sides of the jellyfish head. The head is linked to the body of the subducting slab by a thin tail. A complete parametric study reveals that subducting slabs may achieve a variety of shapes, in good agreement with the diversity of natural slab shapes evidenced by seismic tomography. Our work also suggests that the slab to mantle viscosity ratio in the Earth is most likely to be lower than 100. However, the sensitivity of slab shapes to upper and lower mantle viscosities and densities, which remain poorly constrained by independent evidence, precludes any systematic deciphering of the observations

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Commonalities and Contrasts: an Investigation of ERP Usability an a Comparative User Study

In recent years, several user studies have examined specific usability problems in the field of Enterprise Resource Planning (ERP). These studies focused on different branches, various usability aspects, and several user groups. In spite of this diversification, some common and essential usability problems have become apparent, which are related to system complexity and difficulties in finding required information. However, these findings are based on the situation in a specific country, a singular ERP system and few data samples. Therefore, this paper aims at complementing the related work by results from a comparative user survey from two different European countries: Germany and Latvia. The survey is based on 184 ERP users from Germany and 24 ERP users from Latvia. The results indicated that both countries have several contrasts, but also diverse commonalities in industry, ERP market and culture. However, users in both countries are very homogenous with regard to the assessment of usability problems in their ERP interfaces. This paper investigates elementary usability problems derived from the related work and examines to which extent they are valid in both countries today. The main hypothesis claims that diverse national characteristics do not necessarily lead to a different assessment of usability problems in ERP systems

COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke (COTTIS): a pilot study

Background To evaluate the feasibility and safety of a fast initiation of cooling to a target temperature of 35°C by means of transnasal cooling in patients with anterior circulation large vessel occlusion (LVO) undergoing endovascular thrombectomy (EVT).Methods Patients with an LVO onset of <24 hour who had an indication for EVT were included in the study. Transnasal cooling (RhinoChill) was initiated immediately after the patient was intubated for EVT and continued until an oesophageal target temperature of 35°C was reached. Hypothermia was maintained with surface cooling for 6-hour postrecanalisation, followed by active rewarming (+0.2°C/hour). The primary outcome was defined as the time required to reach 35°C, while secondary outcomes comprised clinical, radiological and safety parameters.Results Twenty-two patients (median age, 77 years) were included in the study (14 received additional thrombolysis, 4 additional stenting of the proximal internal carotid artery). The median time intervals were 309 min for last-seen-normal-to-groin, 58 min for door-to-cooling-initiation, 65 min for door-to-groin and 123 min for door-to-recanalisation. The target temperature of 35°C was reached within 30 min (range 13–78 min), corresponding to a cooling rate of 2.6 °C/hour. On recanalisation, 86% of the patients had a body temperature of ≤35°C. The median National Institutes of Health Stroke Scale at admission was 15 and improved to 2 by day 7, and 68% of patients had a good outcome (modified Rankin Scale 0–2) at 3 months. Postprocedure complications included asymptomatic bradycardia (32%), pneumonia (18%) and asymptomatic haemorrhagic transformation (18%).Conclusion The combined application of hypothermia and thrombectomy was found to be feasible in sedated and ventilated patents. Adverse events were comparable to those previously described for EVT in the absence of hypothermia. The effect of this procedure will next be evaluated in the randomised COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke-2 trial

Modeling the water masses of the Atlantic Ocean at the Last Glacial Maximum.

We produced gridded monthly sea-surface boundary conditions for the Atlantic Ocean at the Last Glacial Maximum (LGM) based on the sea-surface temperature reconstruction of the GLAMAP project. We used an ocean general circulation model (OGCM), subject to these sea-surface boundary conditions and a corresponding wind stress field from an atmospheric general circulation model, to study the differences in the distribution of the main water masses between the LGM and the present. Our global OGCM is characterized by high vertical resolution, low vertical diffusion, and isopycnal mixing and hence allows for a realistic representation of the hydrology and circulation of the modern Atlantic Ocean. According to a series of LGM experiments with an increasing sea-surface salinity anomaly in the Weddell Sea, the ventilated thermocline was colder than today by 2-3 deg C in the North Atlantic Ocean and, in the experiment with the largest anomaly (1.0 beyond the global anomaly), by 4-5 deg C in the South Atlantic Ocean. Its depth was reduced by 50 m on average, most notably in the tropics. In the North Atlantic Ocean the outcrop locations of the thermocline isopycnal surfaces migrated southward by 5-10 degrees, and the ventilation increased. In the South Atlantic Ocean the mixed layer and thermocline water masses were dominated by cold water originating from Drake Passage, and the import of warm water from the Indian Ocean was reduced to about 4 Sv or 40% of its modern value. Antarctic Intermediate Water was colder by 3-4 deg C and could be traced as far as 10 N. The meridional overturning rates of North Atlantic Deep Water (NADW) and Antarctic Bottom Water (AABW) in the Atlantic Ocean were similar to those of the present-day experiment (9 10 Sv and 4 Sv, respectively). However, NADW cooled by 2.5 deg C and AABW by 1 deg C. AABW was near the freezing point of seawater at the surface and the saltiest water mass in the Atlantic Ocean, even saltier than NADW. We show that the differences between the LGM and the present-day experiments can be traced back to the changes in the subpolar and interhemispheric sea-surface density gradients